Publications by authors named "H H Janssens"
Introduction: Lumacaftor/ivacaftor (lum/iva) was introduced in the Netherlands in 2017. We investigated 1-year efficacy of lum/iva on lung function and small airway and structural lung disease evaluated by multiple breath nitrogen washout and CT scan. Additionally, we investigated effects of lum/iva on exacerbations, anthropometry, sweat chloride and safety in children with CF in the Netherlands.
View Article and Find Full Text PDFBrassinosteroids (BRs) are steroidal phytohormones indispensable for plant growth, development, and responses to environmental stresses. The export of bioactive BRs to the apoplast is essential for BR signaling initiation, which requires binding of a BR molecule to the extracellular domains of the plasma membrane-localized receptor complex. We have previously shown that the Arabidopsis thaliana ATP-binding cassette (ABC) transporter ABCB19 functions as a BR exporter and, together with its close homolog ABCB1, positively regulates BR signaling.
View Article and Find Full Text PDFObjective: General practitioners (GPs) diagnose the majority of all gout patients. They make their diagnosis clinically. Serum uric acid (SUA) level >0.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how specific lipid mediators (LMs) relate to lung inflammation in young cystic fibrosis (CF) patients, focusing on their levels during early disease progression.
- Researchers analyzed bronchoalveolar lavage fluid (BALF) samples from children aged 1-5, finding that certain omega-3 and omega-6 fatty acid derivatives correlated with neutrophilic inflammation and lung damage.
- The results indicate a shift from linoleic acid (LA) derivatives to arachidonic acid (AA) derivatives in the lung lipid profile, suggesting that this change is associated with the progression of lung disease in CF.