Risk factors of recurrent periprosthetic joint infection of the knee after two-stage reimplantation.

Introduction: Prosthetic joint infection (PJI) is one of the most common and detrimental complications of total knee replacement arthroplasty (TKA). Despite extensive efforts, including two-stage reimplantation, to eradicate PJI, it still recurs in a substantial number of patients. However, the risk factors of recurrence after two-stage reimplantation of the knee have not been established.

Intra-arterial tenecteplase after successful endovascular recanalisation in patients with acute posterior circulation arterial occlusion (ATTENTION-IA): multicentre randomised controlled trial.

Objective: To assess whether intra-arterial tenecteplase administered after successful endovascular recanalisation improves outcomes in patients with acute arterial occlusion of the posterior circulation.

Design: Multicentre randomised controlled trial.

Setting: 31 hospitals in China, 24 January 2023 to 24 August 2023.

Efficacy and safety of topical cream containing aminoacryl tRNA synthetase complex interacting 1-derived peptide in mitigating radiation dermatitis after adjuvant radiotherapy for breast cancer.

Purpose: Acute radiation dermatitis (ARD) is a frequent side effect experienced by breast cancer patients undergoing radiotherapy. This study aimed to assess the efficacy and safety of a topical cream containing aminoacryl tRNA synthetase complex interacting 1 (AIMP1)-derived peptide (AdP) in mitigating radiation dermatitis (RD) in breast cancer patients undergoing radiotherapy.

Methods: An 8-week single-center, prospective pilot study was conducted to compare the clinical efficacy and safety of an AdP-containing cream with a control cream lacking AdP for the mitigation of RD.

Bridging the gap between gut microbiota and sleep disorders through intermediary metabolites.

Background: Research has suggested an interaction between gut microbiota and sleep, yet the causal relationships between gut microbiota, metabolites, and sleep disorders remain unclear. This study aims to uncover these relationships.

Methods: We obtained genome-wide data for 196 gut microbiota species (N = 18,340), 1400 metabolites (N = 8299), and sleep disorders (N = 361,194).

Nlnemo suppresses of BMP signaling in wing development of the brown planthopper, Nilaparvata lugens.

Nemo-like kinases (NLKs) integrate multiple signaling pathways and exhibit functional diversity in developmental processes, including the bone morphogenetic protein (BMP) pathway. However, their roles in insect wing development, particularly in hemimetabolous insects like the brown planthopper (Nilaparvata lugens), remain poorly understood. Here, we investigated the role of Nlnemo (Nlnmo), an NLK, in the wing development of N.