Publications by authors named "H H Draper"
Background: There are few data on the treatment of children and adolescents with multidrug-resistant (MDR) or rifampicin-resistant (RR) tuberculosis, especially with more recently available drugs and regimens. We aimed to describe the clinical and treatment characteristics and their associations with treatment outcomes in this susceptible population.
Methods: We conducted a systematic review and individual participant data meta-analysis.
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- Ovarian torsion (OT) is a rare but critical gynecological emergency that requires quick diagnosis and management, leading researchers to explore non-invasive biomarkers for detection.
- A systematic review of literature from five databases examined studies on biomarkers related to OT, resulting in the inclusion of 23 articles that reported on both animal and human research.
- Key biomarkers identified included ischemia-modified albumin (IMA), serum D-dimer (s-DD), and interleukin-6 (IL-6), with specificities reaching 93.3% and sensitivities ranging from 16.4% to 92.3%, indicating their potential for early identification of OT in patients.
Background: Skin cancer is the most common cancer worldwide. Early diagnosis is crucial for improving patient survival and morbidity. Artificial intelligence (AI)-assisted smartphone applications (apps) for skin cancer potentially offer accessible, early risk assessment of suspicious skin lesions.
View Article and Find Full Text PDFBackground: Linezolid, a component of rifampicin-resistant/multidrug-resistant tuberculosis (RR/MDR-TB) treatment, is associated with treatment-limiting toxicities, including anemia. Patient-level and linezolid pharmacokinetic risk factors for anemia have not been well described in children treated for RR/MDR-TB.
Methods: We evaluated the pharmacokinetics of linezolid and longitudinal hemoglobin data to validate an existing population linezolid pharmacokinetic model.