Publications by authors named "H Guegan"
Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) is a life-threatening complication in patients with severe COVID-19. Previously, acute respiratory distress syndrome in patients with COVID-19 has been associated with lung fungal dysbiosis, evidenced by reduced microbial diversity and colonization. Increased fungal burden in the lungs of critically ill COVID-19 patients is linked to prolonged mechanical ventilation and increased mortality.
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- Siderophores are iron-scavenging compounds secreted by certain fungal strains during their growth, playing a role in their virulence and potential use as clinical biomarkers for invasive infections like scedosporiosis and lomentosporiosis.
- The strains produced various types of siderophores, with -methyl-coprogen B being the most abundant and secreted faster, particularly under conditions of limited iron and zinc, which may increase their virulence.
- Additionally, two new cyclic peptides were identified using advanced sequencing, and the detection methods for coprogens were refined, suggesting they could be valuable tools for diagnosing these infections in clinical settings.
Article Synopsis
- Superficial fungal infections from dermatophytes are common and diagnosing them quickly is important for effective treatment, but traditional methods like fungal culture have drawbacks, including slow results and variable accuracy.
- This study tested the Novaplex dermatophyte assay (a type of real-time PCR) against standard mycological methods using 312 samples and found PCR had a high concordance rate of 87.2% compared to culture methods.
- While the Novaplex assay shows promise with high sensitivity (up to 100% for some targets) and specificity (96.6% for PCR), it cannot fully replace traditional methods since it doesn't detect all mold infections or identify specific dermatophyte species.
Critically ill patients admitted to the intensive care unit (ICU) for SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) are at increased risk of bacterial and fungal secondary pulmonary infections due to acquired immune dysfunction. Given that the activity of neutrophils has not been described in these patients, we aimed to investigate the function of neutrophils at ICU admission and on day 7 (D7) postadmission. Neutrophil maturation and several functional indicators were investigated.
View Article and Find Full Text PDFObjectives: This study aims to assess the urinary diffusion and clinical effectiveness of voriconazole in patients with fluconazole-resistant urinary candidiasis.
Patients And Methods: In this prospective pilot study, we utilized a validated chromatography method to measure voriconazole in urine over a 12-hour period between two administrations of the drug and in plasma at trough.
Results: Thirty-five patients, including five with fluconazole-resistant urinary candidiasis, were included.