Publications by authors named "H Grut"
Introduction: To determine whether heterogeneity in colorectal liver metastases (CRLM) F fluorodeoxyglucose [F]FDG distribution is predictive of disease-free survival (DFS) and overall survival (OS) following liver transplantation (LT) for unresectable CRLM.
Methods: The preoperative [F]FDG positron emission tomography/computed tomography examinations of all patients in the secondary cancer 1 and 2 studies were retrospectively assessed. Maximum standardized uptake value (SUV), metabolic tumour volume (MTV), and six texture heterogeneity parameters (joint entropy dissimilarity grey level variance size zone variance and zone percentage, and morphological feature convex deficiency) were obtained.
Article Synopsis
- The study investigates how metabolic tumor volume (MTV) of liver metastases from F-FDG PET/CT can predict long-term survival outcomes (disease-free survival, overall survival, and survival after relapse) in colorectal cancer patients after liver transplantation.
- It finds that patients with low MTV and a low number of metastases have significantly longer overall survival (151 months) compared to those with high MTV (26 months).
- Additionally, even patients with a high number of metastases can experience favorable survival outcomes if they maintain a low MTV, suggesting that MTV could be a critical factor in prognosis after liver transplantation.
Importance: Liver transplant for colorectal cancer with liver metastases was abandoned in the 1990s due to poor overall survival. From 2006, liver transplant for in nonresectable colorectal liver metastases has been reexamined through different prospective trials.
Objective: To determine predictive factors for transplant long-term survival and cure after liver transplant.
The objective of the study was to determine the impact of PET uptake on liver metastases on overall survival (OS) after resection of pulmonary metastases in patients who had received liver transplantation (LT) due to unresectable colorectal liver-only metastases. Resection of pulmonary colorectal metastases is controversial. Some hospitals offer this treatment to selected patients, whereas other hospitals do not perform the procedure in colorectal cancer patients who develop pulmonary metastases.
View Article and Find Full Text PDFObjective: To report 15 years of experience with metabolic tumor volume (MTV) of liver metastases from the preoperative F-FDG PET/CT to predict long-term survival after liver transplantation (LT) for unresectable colorectal liver metastases (CRLM).
Methods: The preoperative F-FDG PET/CT from all SECA 1 and 2 patients was evaluated. MTV was obtained from all liver metastases.