Berardinelli-Seip Congenital Lipodystrophy Discovered Following a STEMI Event.

Unlabelled: A 60-year-old man, with a history of familial lipodystrophy, hypertriglyceridaemia, hepatic steatosis and bone cysts, was admitted due an acute coronary event. Coronary angiography showed significant stenosis in the left anterior descending artery, which was treated. Transthoracic echocardiography showed a slightly dilated left ventricle with diffuse and heterogeneous thickening of its walls, slightly decreased left ventricular function and reduced global longitudinal strain.

Systemic sclerosis in a patient with muscle dystrophy.

Systemic sclerosis is an autoimmune disease that can result in lung fibrosis, and is strongly associated with the presence of serum anti-topoisomerase-I autoantibodies. A young man with genetic muscular dystrophy caused by titin-cap/telethonin () gene mutation, developed a severe restrictive lung disease due to a fibrosing interstitial pneumonia secondary to systemic sclerosis with positive anti-topoisomerase-I antibodies. Using amino acid sequence alignment and protein structure modelling, we found that mutant telethonin exposes an amino acid sequence with significant homology to an immunodominant site of topoisomerase-I.

Household Rituals and Merchant Caravanners: The Phenomenon of Early Bronze Age Donkey Burials from Tell eṣ-Ṣâfi/Gath, Israel.

Most studies of ritual and symbolism in early complex societies of the Near East have focused on elite and/or public behavioural domains. However, the vast bulk of the population would not have been able to fully participate in such public displays. This paper explores the zooarchaeological and associated archaeological evidence for household rituals in lower-stratum residences in the Early Bronze Age (EB) of the southern Levant.