Publications by authors named "H Goyeau"
Article Synopsis
- Understanding the genetic basis of how pathogens affect plants is critical for managing fungal diseases, particularly in the context of quantitative traits rather than just strong resistance.
- Using the Zymoseptoria tritici-wheat model, researchers identified 19 key genes linked to quantitative pathogenicity through a comprehensive genome-wide association study.
- The study reveals that genetic diversity, driven by sequence changes and recombination, plays a significant role in how pathogens adapt and affect plants, emphasizing the importance of certain genes in influencing pathogenic traits.
Deploying disease-resistant cultivars is one of the most effective control strategies to manage crop diseases such as wheat leaf rust, caused by Puccinia triticina. After harvest, this biotrophic fungal pathogen can survive on wheat volunteers present at landscape scale and constitute a local source of primary inoculum for the next cropping season. In this study, we characterised the diversity of P.
View Article and Find Full Text PDFObjective: To determine whether a multicomponent intervention based on physical activity with technological support and nutritional counselling prevents mobility disability in older adults with physical frailty and sarcopenia.
Design: Evaluator blinded, randomised controlled trial.
Setting: 16 clinical sites across 11 European countries, January 2016 to 31 October 2019.
Severe hypoglycaemia (SH) remains a challenge to people with type 1 diabetes (T1DM), and new-generation basal insulins may improve patient outcomes. This post hoc meta-analysis explored the risk of SH with insulin glargine 300 U/mL (Gla-300) versus glargine 100 U/mL (Gla-100) in a pooled population with T1DM from three randomized, multicentre, 6-month similarly designed phase 3 trials: EDITION 4, EDITION JP 1 and EDITION JUNIOR. Endpoints included incidence and time to first occurrence of SH.
View Article and Find Full Text PDFEfficacy and Safety of Insulin Glargine 300 Units/mL (Gla-300) Versus Insulin Glargine 100 Units/mL (Gla-100) in Children and Adolescents (6-17 years) With Type 1 Diabetes: Results of the EDITION JUNIOR Randomized Controlled Trial.
Diabetes Care
July 2020
Objective: To compare efficacy and safety of insulin glargine 300 units/mL (Gla-300) and 100 units/mL (Gla-100) in children and adolescents (6-17 years old) with type 1 diabetes.
Research Design And Methods: EDITION JUNIOR was a noninferiority, international, open-label, two-arm, parallel-group, phase 3b trial. Participants were randomized 1:1 to Gla-300 or Gla-100, titrated to achieve fasting self-monitored plasma glucose levels of 90-130 mg/dL (5.