Publications by authors named "H Gottrup"
Article Synopsis
- A nationwide study in Denmark from 2010 to 2020 analyzed the relationship between socioeconomic status (SES) and poststroke dementia (PSD) among stroke patients, focusing on income, education, and employment.
- The study included 98,489 patients and found that those with low SES had significantly higher rates of PSD, with low income linked to a 1.24 times increase, low education to a 1.11 times increase, and unemployment to a 1.57 times increase in dementia rates.
- Disparities were more pronounced in certain groups, notably women, immigrants, and patients younger than 70, indicating that socioeconomic factors play a crucial role in long-term stroke outcomes beyond typical risk factors.
Introduction: Microglial responses are an integral part of Alzheimer's disease (AD) pathology and are associated with amyloid beta (Aβ) deposition. This study aimed to investigate the effects of Aβ and microglial responses on global cognitive impairment.
Methods: In this longitudinal study, 28 patients with mild cognitive impairment and 11 healthy controls underwent C-PK11195 and C-Pittsburgh compound B positron emission tomography (PET), structural magnetic resonance imaging scans, and global cognitive ratings at baseline and 2-year follow-up.
Introduction: The a-Synuclein Origin and Connectome (SOC) model of Lewy body diseases postulates that a-syuclein will be asymmetrically distributed in some patients with Lewy body diseases, potentially leading to asymmetric neuronal dysfunction and symptoms.
Methods: We included two patient groups: 19 non-demented Parkinson's disease (nPD) patients with [F]FDG PET and motor symptoms assessed by UPDRS-III, and 65 Lewy body dementia (LBD) patients with [F]FDG PET and dopamine radioisotope imaging. Asymmetry indices were calculated for [F]FDG PET by including the cortex for each hemisphere, for dopamine radioisotope imaging by including the putamen and caudate separately, and for motor symptoms by using the difference between right-left UPDRS-III score.
Background: Patients with young onset Alzheimer's disease (YOAD) face long diagnostic delays. Prescription medication use may provide insights into early signs and symptoms, which may help facilitate timely diagnosis.
Methods: In a register-based nested case-control study, we examined medication use for everyone diagnosed with YOAD in a Danish memory clinic during 2016-2020 compared to cognitively healthy controls.
Introduction: Early symptoms in young onset Alzheimer's disease (YOAD) may be misinterpreted, causing delayed diagnosis. This population-based study aimed to map morbidity prior to YOAD diagnosis.
Methods: In a register-based incidence density matched nested case-control study, we examined hospital-diagnosed morbidity for people diagnosed with YOAD in Danish memory clinics during 2016-2020 compared to controls in a 10-year period.