Publications by authors named "H Gosker"
Objectives: Little is known about the effect of bronchoscopic lung volume reduction using endobronchial valves (BLVR-EBV) on extrapulmonary manifestations like body composition, muscle function or metabolism. Pulmonary rehabilitation (PR) clearly addresses extrapulmonary manifestations of COPD, including physical inactivity and low muscle mass. However, the added impact of BLVR-EBV+PR remains unknown.
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- - The study explores the effects of different exercise training methods—high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)—on extra-pulmonary symptoms of chronic obstructive pulmonary disease (COPD), as well as their impact on cognitive and muscle function compared to healthy controls.
- - Conducted as a multi-center, randomized controlled trial, the research involves two phases: the first examines the immediate effects of a 12-week HIIT vs. MICT regimen, while the second phase tracks the long-term impact on cognitive decline and inflammation over 24 months.
- - Key outcomes include improvements in cognitive function, cardiorespiratory fitness, and muscle strength, with additional assessments of neuroinflammation
Article Synopsis
- COPD leads to muscle dysfunction, which may be linked to the spatial relationship between satellite cells and capillaries in muscle tissue.
- A study compared muscle biopsies from 18 COPD patients and 18 healthy older adults, assessing muscle fiber types, satellite cell numbers, and capillary proximity.
- Results showed COPD patients had more type II muscle fibers, reduced capillarisation, and greater distances between satellite cells and capillaries, potentially impacting satellite cell function in COPD.
Background & Aims: Patients with advanced COPD often have difficulty maintaining sufficient dietary intake. Chemosensory function influences food choice and intake but is often overlooked in dietary assessment and intervention strategies. This study aimed to assess differences in chemosensory function and hedonic evaluation of food between patients with COPD and age- and gender-matched healthy controls.
View Article and Find Full Text PDFBackground: COVID-19 has demonstrated a highly variable disease course, from asymptomatic to severe illness and eventually death. Clinical parameters, as included in the 4C Mortality Score, can predict mortality accurately in COVID-19. Additionally, CT scan-derived low muscle and high adipose tissue cross-sectional areas (CSAs) have been associated with adverse outcomes in COVID-19.
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