Chronic Offending and Its Relation to Homicide in a Large, Prospective Brazilian Birth Cohort.

Background: Many studies have found that a small group of chronic offenders is responsible for the majority of crimes and tend to be particularly violent. However, there is a major lack of evidence on chronic offending in low- and middle-income countries; understanding these patterns is especially important in settings with very high levels of serious violence, such as Brazil.

Aims: To identify the extent that crime is concentrated in chronic offenders and linked to violence and homicide in a Brazilian cohort.

Effectiveness of aspiration and the occurrence of adverse effects using the intramuscular route in adults: a systematic review protocol.

Objective: The objective of this review will be to evaluate the effect of prior aspiration versus non-aspiration during intramuscular injection on the occurrence of adverse effects in adult patients.

Introduction: Aspiration is a procedure conducted prior to the administration of intramuscular medications that aims to ensure that the needle tip is inserted in the proper place. Although aspiration is a common procedure, questions have been raised about adverse effects.

Advances in Tumor-Infiltrating Lymphocyte (TIL) as a Prognostic Factor and for Treating Invasive Cutaneous Melanoma.

Invasive cutaneous melanoma is responsible for about 5% of skin tumors yet is liable for nearly 70% of skin cancer-related deaths. Despite notable advancements over the past decade, including immunotherapies and targeted treatments, more than half of invasive melanoma patients ultimately succumb to the disease due to therapeutic resistance. To overcome this obstacle, strategies such as combining immunotherapies with targeted drugs or adding epigenetic therapies have been investigated.