Publications by authors named "H Golding"
We performed a systems vaccinology analysis to investigate immune responses in humans to an H5N1 influenza vaccine, with and without the AS03 adjuvant, to identify factors influencing antibody response magnitude and durability. Our findings revealed a platelet and adhesion-related blood transcriptional signature on day 7 that predicted the longevity of the antibody response, suggesting a potential role for platelets in modulating antibody response durability. As platelets originate from megakaryocytes, we explored the effect of thrombopoietin (TPO)-mediated megakaryocyte activation on antibody response longevity.
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- The study examines how the adjuvant AS03 affects vaccination responses in humans receiving the H5N1 influenza vaccine by analyzing data over 14 time points, including the immediate aftermath of the vaccination.
- Researchers developed a computational method to identify complex immune response patterns, revealing differences in how the immune system responds to the vaccine with and without the adjuvant at different stages of vaccination (prime and boost).
- Findings indicate that certain immune response signatures persist long after vaccination, and specific immune cell characteristics, particularly in monocytes and CD8 T cells, are associated with stronger antibody responses, suggesting that pre-existing immune states can influence vaccine effectiveness.
Uptake of the COVID-19 vaccine among pregnant persons is lower than the general population. This scoping review explored pregnant people's attitudes towards the COVID-19 vaccine, reasons for vaccine hesitancy, and whether attitudes about COVID-19 vaccines differ by country of origin. A scoping review was conducted across PubMed, Embase, CINHAL, and Scopus.
View Article and Find Full Text PDFThe emergence of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.
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