Publications by authors named "H Girouard"
Hypertension, a multifactorial chronic inflammatory condition, is an important risk factor for neurovascular and neurodegenerative diseases, including stroke and Alzheimer's disease. These diseases have been associated with higher concentrations of circulating interleukin (IL)-17A. However, the possible role that IL-17A plays in linking hypertension with neurodegenerative diseases remains to be established.
View Article and Find Full Text PDFIntroduction: In this study, we aimed to target two molecules, transforming growth factor-beta (TGF-β) and dynamin to explore their roles in blood-brain barrier (BBB) disruption in hypertension.
Methods: For this purpose, angiotensin (ANG) II-induced hypertensive mice were treated with SB-431542, an inhibitor of the ALK5/TGF-β type I receptor, and dynasore, an inhibitor of dynamin. Albumin-Alexa fluor 594 was used to assess BBB permeability.
Article Synopsis
- Alzheimer's disease and dementia are significant public health challenges today, prompting research into factors like arterial stiffness and pulse pressure (PP) that could help reduce dementia risk.
- This study examined the link between peripheral PP, arterial stiffness index (ASI), and brain health in 17,984 UK Biobank participants, aiming to see if ASI is a more accurate indicator of white matter integrity than peripheral PP.
- Findings revealed that peripheral PP is a better predictor of white matter integrity than ASI, particularly up to age 75, and raised questions about the relevance of these measures in older adults beyond that age.
Hypertension is an important risk factor for Alzheimer's disease (AD). The pathophysiological mechanisms underlying the relationship between AD and hypertension are not fully understood, but they most likely involve microvascular dysfunction and cerebrovascular pathology. Although previous studies have assessed the impact of hypertension on different markers of brain integrity, no study has yet provided a comprehensive comparison of cerebrospinal fluid (CSF) biomarkers and structural brain differences between normotensive and hypertensive groups in a single and large cohort of older adults in relationship to cognitive performances.
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