Publications by authors named "H Geissler"
Sex-related differences among patients undergoing surgical aortic valve replacement-a propensity score matched study.
Interdiscip Cardiovasc Thorac Surg
August 2024
Article Synopsis
- The study aimed to explore differences in characteristics and 2-year outcomes after surgical aortic valve replacement (SAVR) between males and females, using data from two registries involving 933 patients.
- Females had certain clinical differences such as lower body mass index, higher surgical risk scores, and smaller valves compared to males, but these disparities largely disappeared after adjusting for similar baseline characteristics.
- Ultimately, despite a higher initial surgical risk profile, both sexes had comparable outcomes 2 years post-SAVR, indicating no significant differences in overall results based on sex.
Here, we present a cost-effective protocol to differentiate bovine fibro-adipogenic progenitors in a thin hydrogel sheet adherent to 96-well plates. We describe steps for the embedding and culturing of cells in alginate sheets, culture maintenance, and analysis. Compared to alternative three-dimensional (3D) models such as hydrogel-based microfibers, this approach simplifies automation while retaining efficient maturation of adipocytes.
View Article and Find Full Text PDFOstrich meat is characterized by high nutritional value; however, it remains an exotic product in most countries worldwide. In Europe, only few data are available regarding its microbial contamination, prevalence of antimicrobial-resistant bacteria, and safety. Therefore, this study aimed to investigate the microbiological quality and safety of ostrich meat samples ( = 55), each from one animal, produced in Bavaria, Germany.
View Article and Find Full Text PDFObjectives: To develop a pipeline for automated body composition analysis and skeletal muscle assessment with integrated quality control for large-scale application in opportunistic imaging.
Methods: First, a convolutional neural network for extraction of a single slice at the L3/L4 lumbar level was developed on CT scans of 240 patients applying the nnU-Net framework. Second, a 2D competitive dense fully convolutional U-Net for segmentation of visceral and subcutaneous adipose tissue (VAT, SAT), skeletal muscle (SM), and subsequent determination of fatty muscle fraction (FMF) was developed on single CT slices of 1143 patients.
Background: Degenerative aortic valve disease accounts for 10-20% of all cardiac surgical procedures. The impact of pre-existing comorbidities on the outcome of patients undergoing surgical aortic valve replacement (SAVR) needs further research.
Methods: The IMPACT registry is a non-interventional, prospective, open-label, multicenter, international registry with a follow-up of 5 years to assess the impact of pre-existing comorbidities of patients undergoing SAVR with the INSPIRIS RESILIA aortic valve on outcomes.