Antioxidant Properties of Selenophene, Thiophene and Their Aminocarbonitrile Derivatives.

The oxygen radical absorbance capacity (ORAC) method was used to detect the antiperoxyradical ability of organoselenium compounds: selenophene and its derivative, 2-amino-4,5,6,7-tetrahydro-1-selenophene-3-carbonitrile (ATSe); while as a comparison, the sulfur-containing analogue of selenophene-thiophene and its derivative-2-amino-4,5,6,7-tetrahydro-1-thiophene-3-carbonitrile (ATS)-was selected. Cyclic voltammetry (CV), differential pulse voltammetry (DPV) and squarewave voltammetry (SWV) methods were used to determine the redox characteristics of organoselenium and organosulfur compounds. The antiradical activity and capacity of the studied compounds were also measured by using stable radical 2,2'-diphenyl-1-picrylhydrazyl (DPPH).

Antioxidant and electron donating function of hypothalamic polypeptides: galarmin and Gx-NH2.

Chemical mechanisms of antioxidant and electron donating function of the hypothalamic proline-rich polypeptides have been clarified on the molecular level. The antioxidant-chelating property of Galarmin and Gx-NH(2) was established by their capability to inhibit copper(II) dichloride catalyzed H(2)O(2) decomposition, thus preventing formation of HO(*) and HOO(*) radicals. The antiradical activity of Galarmin and Gx-NH(2) was determined by their ability to react with 2,2-diphenyl-1-picrylhydrazyl radical applying differential pulse voltammetry and UV-Vis spectrophotometry methods.