Publications by authors named "H G Schaible"

Musculoskeletal pain has a high prevalence of transition to chronic pain and/or persistence as chronic pain for years or even a lifetime. Possible mechanisms for the development of such pain states are often reflected in inflammatory or neuropathic processes involving, among others, cytokines and other molecules. Since biologics such as blockers of TNF or IL-6 can attenuate inflammation and pain in a subset of patients with rheumatoid arthritis, the question arises to what extent cytokines are involved in the generation of pain in human musculoskeletal diseases.

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Article Synopsis
  • Baricitinib, a Janus kinase inhibitor, helps alleviate rheumatoid arthritis symptoms and pain by affecting joint nociceptors.
  • In studies with rats, baricitinib did not impact normal joint responses but reduced pain signals from inflamed joints, particularly in C-fibers.
  • The drug works by blocking the activation of Stat3, a signaling pathway involved in pain sensitivity, suggesting that it directly influences pain mechanisms in inflamed conditions.
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Interferon-γ (IFNγ) and interleukin-17 (IL-17) are master regulators of innate and adaptive immunity. Here we asked whether these cytokines also regulate pain. Both cytokines increased the excitability of isolated small- to medium-sized sensory neurons, suggesting a pronociceptive effect.

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Objective: Diabetes mellitus (DM) is an important risk factor for the development of osteoarthritis (OA), increasing OA progression and OA pain. To gain insight into the underlying mechanisms of how DM exacerbates OA processes and OA pain, this study analyzed histological differences of synovial tissues from non-DM and DM patients with OA and correlated these differences with knee pain severity.

Materials And Methods: Synovial tissue was obtained from 12 non-DM and 10 DM patients with advanced knee OA who underwent total knee arthroplasty.

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