Publications by authors named "H G Rus"
Background: Insufficient sleep is a problem affecting millions. Poor sleep can trigger or worsen anxiety; conversely, anxiety can lead to or exacerbate poor sleep. Advances in innovative consumer products designed to promote relaxation and support healthy sleep are emerging, and their effectiveness can be evaluated accurately using sleep measurement technologies in the home environment.
View Article and Find Full Text PDFBackground: Insufficient sleep is a problem affecting millions. Poor sleep can instigate or worsen anxiety and, conversely, anxiety can lead to or exacerbate poor sleep. Advances in innovative consumer products designed to promote relaxation and support healthy sleep are emerging and their effectiveness can be evaluated accurately using sleep measurement technologies in the home environment.
View Article and Find Full Text PDFRegular assessment of disease activity in relapsing-remitting multiple sclerosis (RRMS) is required to optimize clinical outcomes. Biomarkers can be a valuable tool for measuring disease activity in multiple sclerosis (MS) if they reflect the pathological processes underlying MS pathogenicity. In this pilot study, we combined multiple biomarkers previously analyzed in RRMS patients into an MS disease activity (MSDA) score to evaluate their ability to predict relapses and treatment response to glatiramer acetate (GA).
View Article and Find Full Text PDFArticle Synopsis
- Systemic lupus erythematosus is an autoimmune disease causing damage to kidneys and organs, which was studied in the context of nephrotoxic nephritis (NTN) as a model for lupus nephritis.
- The research focused on response gene to complement-32 (RGC-32), finding that its absence in RGC-32 knockout (KO) NTN mice led to reduced proteinuria, improved kidney function, and less severe kidney damage.
- RGC-32 KO mice also showed decreased recruitment of certain immune cells and less renal fibrosis, suggesting that RGC-32 could be a promising target for new treatments aimed at combatting conditions like lupus nephritis.
Article Synopsis
- - Liver failure can disrupt the Blood CNS Barrier (BCB), leading to damage in the Central Nervous System (CNS), but the exact mechanisms are not yet fully understood.
- - Researchers developed advanced imaging techniques to study the integrity of the BCB, discovering that specific genetic changes in mice lead to BCB breakdown and subsequent brain damage.
- - The study highlights a potential protective role of a molecule called HFE2, which could prevent BCB dysfunction and offers insights into treating conditions like multiple sclerosis related to blood-brain barrier issues.