Publications by authors named "H G Roggenkamp"
Article Synopsis
- The study examined the predictive value of cytokine levels (MIF and IL-1β) in determining responses to antidepressant treatment in 1,299 patients as part of a larger trial.
- Despite initial findings from smaller studies indicating a link between these cytokines and treatment response, the current research found no significant associations with depression score changes or treatment outcomes.
- The lack of replication raises doubts about the usefulness of these biomarkers in clinical settings for treating depression.
Background: The spread of multi-resistant bacteria endangers the effectiveness of empirical antimicrobial treatment, particularly in Gram-negative bloodstream infections. Thus, rapid and reliable susceptibility testing has become a key challenge of modern microbiology. Here, we evaluated a combination disc test for rapid detection of ESBL production in Escherichia coli (rapid combination disc test, RCDT) directly from blood cultures.
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- The study investigates whether pharmacogenomic testing can improve the selection of antidepressants for patients with major depressive disorder (MDD) and lead to better treatment outcomes compared to standard care.
- Conducted at 22 Veterans Affairs medical centers, the trial involved 1,944 patients and 676 clinicians, assessing the effectiveness of treatment guided by pharmacogenomic results over 24 weeks.
- Results showed a significant portion of the pharmacogenomic-guided group received prescriptions with fewer drug-gene interactions, suggesting potential advantages in using such testing for choosing antidepressants in MDD treatment.
Article Synopsis
- The study focuses on understanding the transmission of SARS-CoV-2 in a German hospital during the second and third pandemic waves, highlighting the burden on healthcare systems due to COVID-19.
- Researchers analyzed 284 samples from patients and staff, using full-length viral genome sequencing to identify infection sources and transmission patterns, while integrating various types of data for a comprehensive understanding.
- Findings indicate that while traditional epidemiological methods can identify most healthcare-associated infections, genomic surveillance is essential to uncover hidden transmission routes and improve response measures, thereby reducing infections despite high community transmission levels.
The role of respiratory superinfections in patients with coronavirus disease 2019 (COVID-19) pneumonia remains unclear. We investigated the prevalence of early- and late-onset superinfections in invasively ventilated patients with COVID-19 pneumonia admitted to our department of intensive care medicine between March 2020 and November 2020. Of the 102 cases, 74 (72.
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