Publications by authors named "H G Nastri"
Article Synopsis
- Mutations in a protein called calreticulin (mutCALR) cause blood disorders known as myeloproliferative neoplasms (MPNs), but there aren’t any treatments specifically targeting this mutation.
- A new antibody called INCA033989 can specifically attack cells with the mutCALR mutation, stopping them from growing and causing problems.
- In tests on mice, INCA033989 not only prevented issues like high blood cell counts but also showed it could help treat the disease without harming normal blood cell production.
CDR: complementarity determining region; FACS: fluorescence-activated cell sorting; k: association rate; k: dissociation rate; K: dissociation constant; scFv: single-chain variable fragment; SPR: surface plasmon resonance.
View Article and Find Full Text PDFImmune checkpoint inhibitors demonstrate clinical activity in many tumor types, however, only a fraction of patients benefit. Combining CD137 agonists with these inhibitors increases anti-tumor activity preclinically, but attempts to translate these observations to the clinic have been hampered by systemic toxicity. Here we describe a human CD137xPD-L1 bispecific antibody, MCLA-145, identified through functional screening of agonist- and immune checkpoint inhibitor arm combinations.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the creation of a diverse antibody library from a single healthy individual, challenging the traditional view that more donors equal greater diversity.
- The research emphasizes that the quantity of lymphocytes is more crucial than the number of donors in producing a functional library.
- A high-quality phage display library was constructed, utilizing efficient extraction and amplification methods, and validated through next-generation sequencing, demonstrating successful functionality against various therapeutic targets.