Walter Eichler and his role in the development of electroneurography.

Walter Eichler (1904-1942) performed the first in situ nerve conduction studies in humans. Eichler's work has been largely overlooked and there have been no biographical accounts written of him. His 1937 paper, Über die Ableitung der Aktionspotentiale vom menschlichen Nerven in situ (On the recording of the action potentials from human nerves in situ) was translated and reviewed.

Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma.

Unlabelled: Recurrent CNS lymphoma continues to be associated with poor outcomes in the rituximab era. Although IV rituximab mediates superior disease control of systemic non-Hodgkin lymphoma (NHL), it fails to completely eliminate the risk of meningeal recurrence, likely due to minimal CNS penetration. Given that rituximab acts synergistically with chemotherapy, we conducted the first phase 1 study of intraventricular immunochemotherapy in patients with recurrent CNS NHL.

Semicontinuous low-dose-rate teletherapy for the treatment of recurrent glial brain tumors: final report of a phase I/II study.

Purpose: Semicontinuous low-dose-rate teletherapy (SLDR) is a novel irradiation strategy that exploits the increased radiosensitivity of glial cells in a narrow range of reduced dose rate. We present the final report of a prospective Phase I/II study testing the feasibility of SLDR for the treatment of recurrent gliomas.

Methods And Materials: Patients with previously irradiated recurrent gliomas were enrolled from November 1993 to March 1998.

American influence on the origins of neurosurgery in the Netherlands.

Although the Netherlands played a major role in the revival of craniotomy in the late 19th century, modern neurosurgery made a late start there. Unlike the situation in other European countries, Dutch neurosurgery lacked a protagonist when, at the turn of the last century, craniotomy became less popular due to discouraging results. During two lecture tours in the US in the 1920s and 1930s, the influential Dutch neurologist Bernard Brouwer also visited the leading neurosurgical centers.

The superior longitudinal fasciculus and speech arrest.

We present a 59-year-old woman with recurrent glioblastoma multiforme involving the left medial frontal and cingulate gyri. Diffusion tensor imaging (DTI) showed inferior-lateral tumor border proximity to the superior-medial (supracallosal) portion of the left frontal superior longitudinal fasciculus (SLF). Dissections of the tumor border contacting the dominant SLF caused speech arrests 8 times, with full recovery.