Safety and Efficacy of Imeglimin for Type 2 Diabetes Mellitus in Patients With Heart Failure.

Background/aim: Imeglimin, a novel oral antidiabetic agent, was approved in 2021 for the treatment of type 2 diabetes mellitus (T2DM). Phase III clinical trials demonstrated its safety and efficacy in managing T2DM. However, its safety profile in patients with heart failure has not been thoroughly evaluated in real-world clinical settings.

Excessive supraventricular ectopic activity is a simple cutoff for predicting late recurrence of atrial fibrillation after ablation.

The relationship between post-ablation excessive supraventricular ectopic activity (ESVEA), a new marker for new-onset atrial fibrillation (AF), and late AF recurrence is uncertain. We enrolled 469 patients with AF who underwent initial radiofrequency catheter ablation and 24-h Holter monitoring the day after. Early AF recurrence (n = 57; 12%) and ESVEA (n = 242; 52%) were noted.

Single-channel electroencephalography decomposition by detector-atom network and its pre-trained model.

Signal decomposition techniques utilizing multi-channel spatial features are critical for analyzing, denoising, and classifying electroencephalography (EEG) signals. To facilitate the decomposition of signals recorded with limited channels, this paper presents a novel single-channel decomposition approach that does not rely on multi-channel features. Our model posits that an EEG signal comprises short, shift-invariant waves, referred to as atoms.

New criteria for preoperative liver function assessment with safety margins to avoid postoperative mortality during liver resection for hilar cholangiocarcinoma.

Background: Despite recent medical advancements, surgery for hilar cholangiocarcinoma is associated with high complication and mortality rates. This may be partly attributed to the absence of established preoperative liver evaluation criteria for safe surgery. This study aimed to propose a reliable indicator for safe and well-planned management of major hepatectomy with extrahepatic bile duct resection.