Publications by authors named "H G Fletcher"
Article Synopsis
- The need for more effective tuberculosis (TB) vaccines is crucial, as TB remains the deadliest infectious disease worldwide, but current methods to evaluate potential vaccines are slow and expensive due to unclear immune protection correlates.
- Human-derived correlate of risk (COR) gene signatures could serve as valuable endpoints in preclinical evaluations of TB treatments, allowing for more defined and practical assessments.
- The study identifies specific COR signatures, like RISK6, Sweeney3, and BATF2, which show promise in correlating with disease progression in preclinical models, especially when these models are closely matched to human TB infection conditions.
Background & Aims: Hepatitis E virus (HEV) constitutes a substantial public health burden with ∼20 million human infections annually, including 3.3 million symptomatic cases. Appropriate treatment options for, in particular, immunocompromised patients with HEV infection and pregnant women are lacking, underscoring the urgent need for potent and safe antiviral drugs.
View Article and Find Full Text PDFCharacterization of thioredoxin-thioredoxin reductase system in Filifactor alocis.
Mol Oral Microbiol
February 2025
Introduction: Filifactor alocis is a newly appreciated member of the periodontal community with a strong periodontal disease correlation. Little is known about the survival mechanisms by which F. alocis copes with oxidative stress and establishes the infection within the local inflammatory microenvironment of the periodontal pocket.
View Article and Find Full Text PDFTelehealth was instrumental in NC Medicaid's ability to pro-vide health care during the COVID-19 pandemic. Analyses of utilization and survey data and interviews with key Medicaid payors and providers reveal trends in beneficiary access to and utilization of services, presenting NC Medicaid with opportunities to build upon lessons learned.
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