Publications by authors named "H G Desai"
Neuronal injury, neurodegeneration, and neuroanatomical changes are key pathological features of various neurological disorders, including epilepsy, stroke, traumatic brain injury, Parkinson's disease, autism, and Alzheimer's disease. Accurate quantification of neurons and interneurons in different brain regions is critical for understanding the progression of neurodegenerative disorders in animal models. Traditional scoring methods are often superficial, biased, and unreliable for evaluating neuropathology.
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- - Emulgel is a novel formulation that enhances drug stability and topical delivery by combining emulsion and gel, leading to better skin penetration and extended therapeutic effects.
- - The review discusses the commercial viability of emulgels, covering manufacturing strategies, characterization techniques, and an in-depth market analysis supported by recent case studies and research data from reputable sources.
- - Emulgels show potential for commercialization due to their effective drug delivery and user-friendly nature, but challenges like regulatory complexities need to be addressed for better market access and innovation in the future.
Article Synopsis
- The Pipeline Vantage embolization device is a new fourth-generation tool designed to treat intracranial aneurysms, and this study evaluates its safety and effectiveness.
- The research involved 12 patients, primarily women, with a variety of aneurysm types, and demonstrated a 100% success rate in device deployment without intraoperative complications.
- One postprocedural complication occurred, and the findings represent the first US analysis of this device's use in patients with intracranial aneurysms, highlighting its potential for treating both ruptured and unruptured cases.
Article Synopsis
- - Different dental schools use various methods to evaluate final assessments, commonly relying on objective structured clinical examinations or multiple long cases to measure applied knowledge and skills.
- - As the education landscape evolves, it's crucial to reconsider which skills should be evaluated and how, focusing on attributes that define a qualified dentist, like effective communication and case management.
- - A new dynamic assessment approach has been introduced, featuring interactive scenarios with shifting clinical situations, designed to better evaluate essential skills such as communication, clinical reasoning, and professionalism among graduates.
Purpose: Pathogenic germline variants (PGVs) in a subset of cancer predisposition genes (CPGs) are associated with adult-onset autosomal dominant (AD) cancer susceptibility and life-limiting autosomal recessive (AR) disease. Counseling in adult cancer genetics clinics regarding reproductive risk for PGV heterozygotes is limited.
Methods: Estimated heterozygote frequencies across ancestries were calculated for AD CPGs with AR risk (ATM, BRCA1, BRCA2, BRIP1, FH, NBN, MLH1, MSH2, MSH6, PMS2, RAD51C, SDHA, SDHB, and SDHD) from gnomADv.