Publications by authors named "H G Brink"
The direct discharge of cationic surfactants into environmental matrices has exponentially increased due to their wide application in many products. These compounds and their degraded products disrupt microbial dynamics, hinder plant survival, and affect human health. Therefore, there is an urgent need to develop electroanalytical assessment techniques for their identification, determination, and monitoring.
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- - Nanosized cobalt (Co) particles, in combination with polyaniline (PANI) to create composite nanorods (CNRs), show promise for removing toxic lead ions (Pb⁺) from water, with improved efficiency due to their enhanced surface properties.
- - The PANI-Co CNRs demonstrated a high lead adsorption capacity of 1130 mg/g at 25 °C and achieved equilibrium within 60 to 150 minutes, indicating effective and rapid lead ion removal.
- - Mechanistically, the process involves the adsorption and precipitation of lead onto the CNRs, which is followed by the reduction of lead to its metallic form, while other metal ions, like Cu, can interfere with this
Article Synopsis
- Cerebral amyloid angiopathy (CAA) is a cerebrovascular disease marked by abnormal amyloid-β deposits in blood vessels, commonly found in older adults and Alzheimer's patients.
- The underlying processes that lead to blood vessel damage and related issues, like bleeding and cognitive decline, are not well understood yet.
- This review highlights previous research on neuroinflammation's involvement in CAA and suggests future studies focusing on specific targets like matrix metalloproteinases and activated immune cells to improve treatment options.
Background: White matter hyperintensities (WMHs) are frequently observed on magnetic resonance imaging (MRI) in patients with cerebral amyloid angiopathy (CAA). The neuropathological substrates that underlie WMHs in CAA are unclear, and it remains largely unexplored whether the different WMH distribution patterns associated with CAA (posterior confluent and subcortical multispot) reflect alternative pathophysiological mechanisms.
Methods And Results: We performed a combined in vivo MRI-ex vivo MRI-neuropathological study in patients with definite CAA.
Cancer vaccines are a promising strategy to increase tumor-specific immune responses in patients who do not adequately respond to checkpoint inhibitors. Cancer vaccines that contain patient-specific tumor antigens are most effective but also necessitate the production of patient-specific vaccines. This study aims to develop a versatile cancer vaccine format in which patient-specific tumor antigens can be site-specifically conjugated by a proximity-based Sortase A (SrtA)-mediated ligation (PBSL) approach to antibodies that specifically bind to antigen-presenting cells to stimulate immune responses.
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