Phase I study of neoadjuvant chemoradiotherapy with S-1 for clinically resectable type 4 or large type 3 gastric cancer in elderly patients aged 75 years and older (OGSG1303).

Purpose The prognosis for type 4 and large type 3 gastric cancer (GC) is extremely poor, especially in elderly patients (≥ 75 years). To improve the prognosis of these types of GC, we performed a phase I study to determine the recommended dose (RD) of S-1 combined with neoadjuvant radiotherapy. Methods Patients with clinically resectable type 4 and large type 3 GC were enrolled to successive cohorts in a conventional 3 + 3 design.

Seroprevalence in Rheumatoid Arthritis Patients with Interstitial Lung Disease.

Background: Rheumatoid arthritis (RA) is complicated with interstitial lung disease (ILD). Gastroesophageal reflux disease is prevented by infection and is a predisposing factor for idiopathic pulmonary fibrosis. However, the prevalence of infection in RA patients with ILD has not been sufficiently investigated.

Serum Anti-Aminoacyl-Transfer Ribonucleic Acid Synthetase Antibody Levels Are Involved in Rheumatoid Arthritis Complicated with Interstitial Lung Disease.

A common complication in patients with rheumatoid arthritis (RA) is interstitial lung disease (ILD). Antibodies (Abs) to anti-aminoacyl-transfer ribonucleic acid synthetase (ARS) are linked to ILD in patients with idiopathic inflammatory myopathies (IIM). There have been limited studies of anti-ARS Abs in RA.

High-temperature carbon dioxide capture in a porous material with terminal zinc hydride sites.

Carbon capture can mitigate point-source carbon dioxide (CO) emissions, but hurdles remain that impede the widespread adoption of amine-based technologies. Capturing CO at temperatures closer to those of many industrial exhaust streams (>200°C) is of interest, although metal oxide absorbents that operate at these temperatures typically exhibit sluggish CO absorption kinetics and instability to cycling. Here, we report a porous metal-organic framework featuring terminal zinc hydride sites that reversibly bind CO at temperatures above 200°C-conditions that are unprecedented for intrinsically porous materials.

Enhancement of measurement range of MicroLiDAR with multi-reference paths.

The measurement range of the MicroLiDAR was enhanced with multi-reference paths. The multi-reference paths were composed of four paths with polarization maintaining optical fibers, each with different lengths. 50-mm-long measurement range was demonstrated with an oscilloscope with 15-GHz bandwidth.