Publications by authors named "H Fujishiro"
Article Synopsis
- Managing psychiatric symptoms in dementia with Lewy bodies (DLB) is challenging due to poor responses to antipsychotic medications, prompting the investigation of electroconvulsive therapy (ECT) as a treatment option despite limited prior studies.
- A retrospective study on 25 patients (12 DLB, 13 MCI with LB) showed that ECT significantly improved psychiatric symptoms, with many reporting varying degrees of improvement after treatment.
- While ECT was effective in reducing symptoms and did not worsen cognitive function, some patients experienced side effects like delirium and amnesia.
Anti-cancer drug cisplatin (CDDP) causes severe acute kidney injury (AKI). CDDP-induced AKI does not occur immediately after administration, but rather 6 to 10 days after administration. However, the mechanism underling the delayed renal injury by CDDP is not well understood.
View Article and Find Full Text PDFArsenite increases sialic acid levels on the cellular surface through the inhibition of sialidase activity.
Biochem Biophys Res Commun
December 2024
Chronic exposure to arsenic has been shown to induce carcinogenesis in multiple organs, but the mechanisms underlying the multi-organ carcinogenicity of arsenic remain unknown. We here examined whether arsenic affects the amount of sialic acid on the cellular surface of immortalized HaCaT cells rather than cancerous cells to clarify the process of arsenic-induced carcinogenesis, since sialic acid is known to assist cancer cells in suppressing attacks by natural killer (NK) cells. Our results indicated that exposure to arsenite (As(III)) increases the amounts of sialic acid on the cell surface of HaCaT cells.
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