Publications by authors named "H Fujihara"
This study investigates the effect of reduced saliva production on intestinal histological structure and microbiome composition using a sialoadenectomy murine model, evaluating differences in saliva secretion, body weight, intestinal histopathological changes, and microbiome alteration using 16S rRNA gene sequencing across three groups (control, sham, and sialoadenectomy). For statistical analysis, one-way analysis of variance and multiple comparisons using Bonferroni correction were performed. -values < 0.
View Article and Find Full Text PDFObjectives: It is recommended to adjust the dose of vancomycin (VCM) with a target area under the concentration-time curve (AUC) of 400-600 μg·h/mL. Factors that affect the deviation between AUCs are estimated from the trough value alone and the trough and peak values using practical AUC-guided therapeutic drug monitoring (PAT) for vancomycin. In this study, factors that affect AUC were evaluated.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the prevalence and factors associated with red blood cell (RBC) alloimmunization in transfused patients, focusing on how clinical factors relate to the development and disappearance of RBC antibodies.
- Data from 1194 patients across five institutions showed that 4.6% developed new antibodies after transfusion, with the number of RBC units transfused significantly influencing this outcome.
- The research suggests that antibodies identified through specific testing methods may often fade away quickly and emphasizes the importance of thorough antibody screening, particularly for patients receiving many transfusions, to avoid missing potentially relevant antibody information.
Temperament is a key predictor of human mental health and cognitive and emotional development. Although human fear behavior is reportedly associated with gut microbiome in infancy, infant gut microbiota changes dramatically during the first 5 years, when the diversity and composition of gut microbiome are established. This period is crucial for the development of the prefrontal cortex, which is involved in emotion regulation.
View Article and Find Full Text PDFObjectives: To verify the effects of organizational interventions on mental health using Layered Voice Analysis (LVA).
Methods: A 12-week single-blind randomized controlled trial was conducted with call center operators. Sixty-six participants were randomly assigned to either a control group (n = 26), an LVA intervention group (n = 20), or a one-on-one intervention group (n = 20).