Publications by authors named "H Freitas"
Background: In proton radiotherapy, the steep dose deposition profile near the end of the proton's track, the Bragg peak, ensures a more conformed deposition of dose to the tumor region when compared with conventional radiotherapy while reducing the probability of normal tissue complications. However, uncertainties, as in the proton range, patient geometry, and positioning pose challenges to the precise and secure delivery of the treatment plan (TP). In vivo range determination and dose distribution are pivotal for mitigation of uncertainties, opening the possibility to reduce uncertainty margins and for adaptation of the TP.
View Article and Find Full Text PDFAssociation between vaccination and persistent COVID-19-related symptoms among patients with mild Omicron infection: A prospective cohort study.
Vaccine X
December 2024
Background: While COVID-19 vaccination has been shown to reduce the risk of severe illness, its impact on the occurrence of persistent symptoms in patients with mild Omicron infection remains uncertain. Our objective was to investigate whether COVID-19 vaccination reduces the occurrence of persistent COVID-19-related symptoms 3 months after mild Omicron infection.
Methods: Multicenter prospective cohort study was conducted in Brazil between January 2022 and June 2023 when Omicron was predominant.
Article Synopsis
- * A search of patents revealed 411 related to TB vaccines, with 10 focusing specifically on viral vectors, primarily adenoviruses, showing a peak in filings from 2013 to 2023, mainly from the U.S. and China.
- * Most patents included immunodominant Mtb antigens and were primarily tested in mouse models through intranasal or subcutaneous immunization, indicating a hopeful future for these technologies in TB vaccination and other diseases, alongside a need for safety evaluations.
Article Synopsis
- Tobacco use is a major risk factor for lung cancer, but 10-20% of lung cancer patients are never-smokers, with distinct clinical and genomic differences observed between smokers and never-smokers, especially in Chile.
- This study examines genomic alterations in lung cancer between smokers and never-smokers, focusing on 10 relevant genes, revealing a higher overall frequency of genetic alterations in never-smokers (58%) compared to smokers (45.7%).
- Key findings include that never-smokers tend to have higher alterations in genes like EGFR and PIK3CA, while smokers showcase a more complex genomic profile, particularly with KRAS mutations.