Publications by authors named "H Fragoso-Loyo"
Article Synopsis
- The update of the Mexican Guidelines for the Treatment of Systemic Lupus Erythematosus has been developed with input from various experts across the country.
- The new guidelines follow the GRADE system, which helps in evaluating the quality of evidence for healthcare recommendations.
- Key new topics included in the update are vaccines, pregnancy, and cardiovascular risk, which were not addressed in the previous guidelines from 2017.
Article Synopsis
- Systemic lupus erythematosus (SLE) significantly increases the risk of cardiovascular disease, prompting a study to evaluate traditional cardiovascular risk factors in SLE patients worldwide between 2015 and 2020.
- The study included 3,401 SLE patients from 24 countries, predominantly women, revealing high rates of hypertension (35.6%), obesity (23.7%), and hyperlipidaemia (19.8%), with poor control of these risk factors across the board.
- Notably, patients with antiphospholipid syndrome had higher prevalence of cardiovascular risks but showed better control of blood pressure and lipid levels compared to those without, highlighting international discrepancies in risk factor management.
Article Synopsis
- Pseudolymphomatous cutaneous angiosarcoma (cAS) is a rare cancer that can be difficult to diagnose due to its similarity to other lymphoid conditions, showcasing notable lymphocyte presence.
- A unique case involving a 47-year-old woman with systemic sclerosis (SSc) is presented, characterized by facial swelling and specific imaging findings that led to a skin biopsy showing unusual vascular patterns and dense lymphocyte growth.
- This case highlights the connection between SSc and higher cancer risk, emphasizing the diagnostic challenges of cAS and the need for early detection and comprehensive management strategies.
Article Synopsis
- - The study assesses the distribution of certified adult and pediatric rheumatologists in Mexico, revealing a total of 1,002 adult and 94 pediatric rheumatologists, with varying gender ratios and average ages.
- - Analysis showed that regions like Mexico City and Jalisco have a higher concentration of rheumatologists, with current certification rates ranging from 65% to 70%, influenced by factors such as age, gender, and geographic location.
- - The research highlights a significant shortage of rheumatologists, particularly in pediatrics, and calls for health policies to improve the regional distribution and certification rates within this specialty.
Objective: Randomised trials of type I anti-CD20 antibodies rituximab and ocrelizumab failed to show benefit in proliferative lupus nephritis (LN). We compared obinutuzumab, a humanised type II anti-CD20 monoclonal antibody that induces potent B-cell depletion, with placebo for the treatment of LN in combination with standard therapies.
Methods: Patients with LN receiving mycophenolate and corticosteroids were randomised to obinutuzumab 1000 mg or placebo on day 1 and weeks 2, 24 and 26, and followed through week 104.