Publications by authors named "H Fosburgh"
Budget impact of next-generation sequencing for diagnosis of TB drug resistance in Moldova.
Int J Tuberc Lung Dis
October 2022
Diagnosing drug resistance is critical for choosing effective TB treatment regimens. Next-generation sequencing (NGS) represents an alternative approach to conventional phenotypic drug susceptibility testing (pDST) for diagnosing TB drug resistance. We undertook a budget impact analysis estimating the costs of introduction and routine use of NGS in the Moldovan National TB Programme.
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- The study highlights the high incidence of multidrug-resistant tuberculosis (MDR-TB) in Moldova, particularly due to the transmission of resistant strains rather than inadequate treatment.
- Researchers analyzed data from 2018-2019, finding that 36% of TB cases were MDR-TB, with half of those never having been treated before.
- The study reveals that spatial and demographic factors play a significant role in transmission, with certain drug-resistant strains clustered geographically, indicating the need for enhanced genomic surveillance to manage the outbreak effectively.
Background: Quality collaboratives are widely endorsed as a potentially effective method for translating and spreading best practices for acute myocardial infarction (AMI) care. Nevertheless, hospital success in improving performance through participation in collaboratives varies markedly. We sought to understand what distinguished hospitals that succeeded in shifting culture and reducing 30-day risk-standardised mortality rate (RSMR) after AMI through their participation in the Leadership Saves Lives (LSL) collaborative.
View Article and Find Full Text PDFBackground: Because organizational culture is increasingly understood as fundamental to achieving high performance in hospital and other healthcare settings, the ability to measure this nuanced concept empirically has gained importance. Aside from measures of patient safety culture, no measure of organizational culture has been widely endorsed in the medical literature, limiting replication of previous findings and broader use in interventional studies.
Methods And Results: We sought to develop and assess the validity and reliability of a scale for assessing organizational culture in the context of hospitals' efforts to reducing 30-day risk-standardized mortality after acute myocardial infarction.