Publications by authors named "H Follet"
Article Synopsis
- - The study addresses the need for reliable methods to predict the risk of fractures in patients with femoral metastases, highlighting the limitations of current clinical tools and the potential of CT-scan-based finite element analysis for better predictions.
- - Researchers assessed the reproducibility of a promising model developed in Belgium by comparing it to an independently reproduced model in France, confirming a strong correlation but noting the reproduced model consistently predicts higher failure loads.
- - The evaluation of the model's application on different datasets showed decreased accuracy in predictions, while the global sensitivity analysis revealed significant factors affecting results, especially the influence of the density calibration coefficient.
Article Synopsis
- - Osteocytes play a crucial role in bone mechanobiology by communicating mechanical signals through the interconnected lacunocanalicular network (LCN) filled with interstitial fluid.
- - This study aimed to gather detailed morphological data on the human LCN using advanced imaging techniques, specifically measuring 27 femoral bone samples with a 100 nm voxel size.
- - Results showed variability in canalicular morphology, with some differences between males and females, although only larger canaliculi were detected; this research is groundbreaking as it presents new data for further investigations on LCN permeability.
Article Synopsis
- * Manual segmentation is often tedious and can vary between experts, prompting the use of deep learning techniques to automate the process even when data is limited.
- * The study develops a specialized pipeline using U-Net architectures for segmenting human femurs and vertebrae, showing that automated segmentation yields results comparable to manual methods in failure load simulations, highlighting its potential effectiveness.
Osteopontin (OPN) and Bone Sialoprotein (BSP), abundantly expressed by osteoblasts and osteoclasts, appear to have important, partly overlapping functions in bone. In gene-knockout (KO, -/-) models of either protein and their double (D)KO in the same CD1/129 genetic background, we analyzed the morphology, matrix characteristics, and biomechanical properties of femur bone in 2 and 4 month old, male and female mice. OPN mice display inconsistent, perhaps localized hypermineralization, while the BSP are hypomineralized throughout ages and sexes, and the low mineralization of young DKO mice recovers with age.
View Article and Find Full Text PDFAging is associated with detrimental bone loss leading to fragility fractures in both men and women. Notably, a majority of bone loss with aging is cortical, as well as a large number of fractures are non-vertebral and at the non-hip sites. Nacre is a product of mollusks composed of calcium carbonate embedded in organic components.
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