Publications by authors named "H Fiegel"
Diagnosis of Hirschsprung disease by analyzing acetylcholinesterase staining using artificial intelligence.
J Pediatr Gastroenterol Nutr
September 2024
Article Synopsis
- Classical Hirschsprung disease (HD) is characterized by the lack of nerve cells in the colon, diagnosed via rectal biopsy showing aganglionosis and cholinergic hyperinnervation, but biopsy methods can affect accuracy.
- A study analyzed 190 samples from patients using digital imaging software to assess acetylcholinesterase (AChE) staining and utilized machine learning to detect patterns of hyperinnervation.
- Results indicated that AChE staining was significantly higher in HD patients than in healthy individuals, and machine learning models demonstrated high accuracy in diagnosing HD, particularly when excluding non-rectal samples.
The biology of cancer stem cells (CSCs) of pediatric cancers, such as hepatoblastoma, is sparsely explored. This is mainly due to the very immature nature of these tumors, which complicates the distinction of CSCs from the other tumor cells. Previously, we identified a CSC population in hepatoblastoma cell lines expressing the CSC markers CD34 and CD90, cell surface Vimentin (csVimentin) and binding of OV-6.
View Article and Find Full Text PDFObjectives: Ovarian lesions are rare but frequent in children. Patients could present with abdominal pain, but ovarian lesions could also be incidentally found on ultrasound. Awareness is required in cases with acute, severe lower abdominal pain, as ovarian torsion could be the cause.
View Article and Find Full Text PDFSignificant progress has been made in the management of Wilms tumor (WT) in recent years, mostly as a result of collaborative efforts and the implementation of protocol-driven, multimodal therapy. This article offers a comprehensive overview of current multidisciplinary treatment strategies for WT, whilst also addressing recent technical innovations including nephron-sparing surgery (NSS) and minimally invasive approaches. In addition, surgical concepts for the treatment of metastatic disease, advances in tumor imaging technology and potentially prognostic biomarkers will be discussed.
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