Publications by authors named "H Fassihi"
Article Synopsis
- Voriconazole (VOR), an anti-fungal drug, can cause phototoxicity and skin cancer by impairing the DNA repair process known as nucleotide excision repair (NER).
- VOR affects NER not by changing the expression of related genes but by binding to heterochromatin, disrupting the acetylation of histone H3, which is necessary for effective DNA repair.
- Using histone deacetylase inhibitors to restore H3 acetylation can reverse the NER inhibition caused by VOR, suggesting a potential therapeutic strategy to prevent its harmful effects.
Article Synopsis
- The study highlights the effectiveness of traditional therapeutic plasmapheresis (TPE) as a treatment for difficult cases of solar urticaria (SU) that don't respond to common medications.* -
- A specific case involving a patient who underwent 42 TPE procedures over five years showed significant improvement in their condition, as indicated by increased resistance to UV light during testing after treatment.* -
- The research also compares the outcomes of this case with previous studies on TPE for SU, showing that patients with positive intradermal tests generally benefited more from TPE, although some relapsed in a short time.*
Xeroderma pigmentosum (XP) is caused by defective nucleotide excision repair of DNA damage. This results in hypersensitivity to ultraviolet light and increased skin cancer risk, as sunlight-induced photoproducts remain unrepaired. However, many XP patients also display early-onset neurodegeneration, which leads to premature death.
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