Prevalence, Treatment, and Unmet Needs of Migraine in the Middle East: A Systematic Review.

Introduction: Migraine is a debilitating neurological disorder characterized by recurrent throbbing, moderate-to-severe headaches that disrupt daily chores, leisure, and social activities of patients, impacting their overall quality of life (QoL). Despite the high disease burden, there is a scarcity of data on migraines within the Middle East (ME) region. Thus, a systematic literature review (SLR) was conducted to examine epidemiological data, treatment patterns, QoL, and unmet needs regarding migraines in the ME region.

GC-MS analysis, anti-inflammatory and anti-proliferative properties of the aerial parts of three .

Background: Due to their variability and safety, widespread research on phytochemicals continually encourages researchers to study various plants for their potential health benefits.

Objectives: This study aims to explore the phytochemical constituents of the aerial parts of three spp.; , and existed in Egyptian nature using GC-MS analysis and studying their different biological activities in correlation to computational analysis.

The interplay of transcriptional regulator SREBP1 with AMPK promotes lipid biosynthesis in Mucor circinelloides WJ11.

SREBP1 is a transcription factor that influences lipogenesis by regulating key genes associated with lipid biosynthesis, while AMPK, modulates lipid metabolism by regulating acetyl-CoA carboxylase. The exact role of these metabolic regulators in oleaginous microbes remains unclear. This study identified and manipulated the genes encoding SREBP1 (sre1) and α1 subunit of AMPK (ampk-α1) in Mucor circinelloides WJ11.