Analysis of gene expression profiles to elucidate racial differences in African American and White patients with Triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is the second most diagnosed subtype of breast cancer. It is known to be the most aggressive one that lacks known targetable receptors. One of the concerns in TNBC is the disparities in its prevalence and tumor pathogenesis among women with non-Hispanic African American backgrounds.

Effectiveness and tolerability of mirabegron in children with overactive bladder: A retrospective pilot study.

Aims: Mirabegron has promising results for OAB symptoms in adults, although the potential for cardiovascular side effects has caused concern. Efficacy and tolerability in children have not been extensively studied. Effectiveness, tolerability, and side effects of Mirabegron are reported in children with refractory OAB.

Management of paediatric high-grade blunt renal trauma: a 10-year single-centre UK experience.

Objective: To report the management and outcome of paediatric patients sustaining high-grade blunt renal trauma.

Patients And Methods: Medical records were examined for all American Association for the Surgery of Trauma (AAST) grade III-V blunt renal trauma cases admitted to a paediatric trauma centre from 2005 to 2015. Data collected and analysed included: demographics, imaging modalities, management, length of hospital stay (LOS), complications, and follow-up outcomes.

Urinary incontinence - an unusual indication for early vaginoplasty in late presenting congenital adrenal hyperplasia.

Background: Congenital adrenal hyperplasia (CAH) is an autosomal recessive condition leading to deficient cortisol with an incidence of 1/16,000. Patients with CAH typically present early with ambiguous genitalia or as an emergency with adrenal crisis.

Case: We report an atypical late presentation of a 4-year-old girl with pubertal-like symptoms and urinary incontinence, due to a persistent urogenital sinus (UGS).

Granuloma annulare of the penis in a seven-year-old boy.

Subcutaneous granuloma annulare of the penis is rare, with only 10 cases in the world literature. This paper describes the youngest case ever reported and reviews its clinical features and management.