New therapeutic agents for the treatment of NIDDM.

Non-insulin dependent diabetes mellitus (NIDDM) is a heterogeneous disease with a world wide growing prevalence. Insulin resistance, particularly an impaired action of insulin on the glucose metabolism in skeletal muscles, has been assumed to be the primary factor in the pathophysiology of this disease and it is observed years before the precipitation of overt NIDDM. Almost half of the patient population already suffer from macroangiopathy at the time of diagnosis and the overall mortality rate primarily due to coronary heart disease is approximately 2.

Neoadjuvant therapy for cervical cancer.

The stage-by-stage prognosis for cervical cancer patients has not improved in the past decades. Our research work concerning adjuvant chemotherapy for the early stages induced a pilot study with untreated patients in advanced stages. Patients were treated with carboplatin 300 mg/m2 plus ifosfamide 5 g/m2 on day 1.

Fully enzymatic inulin determination in small volume samples without deproteinization.

A fully enzymatic method for the determination of inulin in serum or plasma without deproteinization is described. The assay is carried out by means of a fructose determination after hydrolysis of inulin via inulinase and simultaneous oxidation of the native glucose using glucose oxidase and H2O2. This time-saving procedure of high specificity, sensitivity and accuracy requires only small sample volumes.