Prednimustine (Sterecyt) versus cyclophosphamide both in combination with methotrexate and 5-fluorouracil in the treatment of advanced breast cancer.

153 women with advanced breast cancer were randomly allocated for treatment with SMF [prednimustine (Sterecyt) + methotrexate + 5-fluorouracil, 83 patients] or CMF (cyclophosphamide+methotrexate+5-fluorouracil, 70 patients). Prednimustine was administered orally 100 mg/m2 daily, for 5 days, and cyclophosphamide was administered orally 100 mg/m2, for 14 days, each, every 4 weeks. Methotrexate was given at a dose of 40 mg/m2 and 5-fluorouracil at 600 mg/m2 on day 1 and 8, every 4 weeks.

Carcinoma of the penis: a retrospective review of treatment with iridium mould and external beam irradiation.

This paper is a retrospective review of the treatment of carcinoma of the penis with radiotherapy alone over a 30-year period from 1960-1990 at The Royal London Hospital. During that time, 44 patients aged 31-85 years (mean 63) underwent treatment in our department, all of whom had histologically proven squamous carcinoma. Patients initially treated by surgery and those treated with combined surgery and radiotherapy were excluded from analysis.

Carcinoma of the maxillary antrum treated by pre-operative radiotherapy or radical radiotherapy alone.

The results of pre-operative radical radiotherapy and subsequent maxillary resection are reported in 54 consecutive patients with carcinoma of the maxillary antrum treated at The Royal London Hospital from 1965 to 1989. The actuarial two and five year survivals were 50.3 per cent and 38.

The quality of life after radical radiotherapy for bladder cancer.

The quality of life in 72 patients who had shown a complete response to radiotherapy, using a modified bladder symptom score and the Nottingham health profile, was compared with the quality of life in a similar control group matched for age and sex. There was no significant difference in either group. The records of 69 patients who had undergone post-radiation salvage cystectomy were reviewed, looking specifically at surgical complications.