Publications by authors named "H F HELMHOLZ"
Osteoarthritis (OA) is a significant condition that profoundly impacts synovial joints, including cartilage and subchondral bone plate. Biomaterials that can impede OA progression are a promising alternative or supplement to anti-inflammatory and surgical interventions. Magnesium (Mg) alloys known for bone regeneration potential were assessed in the form of Mg microparticles regarding their impact on tissue regeneration and prevention of OA progression.
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- - Mg-Li alloys may serve as effective bioresorbable implants that release lithium (Li) for treating bipolar and neurodegenerative disorders, potentially offering advantages over traditional Li salts.
- - In a study utilizing a neuroinflammation model, two Mg-Li alloys (Mg-1.6Li and Mg-9.5Li) were tested, showing that Li from these alloys enhanced the phosphorylation of GSK3β in glial cells more effectively than Li salts.
- - The results indicate that Mg-Li alloys can improve the modulation of inflammation-related gene expression and support further exploration of their therapeutic potential in neurological treatments.
Article Synopsis
- Magnesium (Mg) alloys, particularly those with gadolinium, are emerging as promising materials for temporary bone implants due to their biocompatibility and mechanical properties, presenting a potential replacement for traditional titanium and stainless-steel implants.
- A study involving rat tibias over various time periods (10, 20, and 32 weeks) used advanced imaging techniques to evaluate the implants' degradation behavior and their integration with bone tissues.
- Results indicate that the Mg-xGd implants not only form a stable degradation layer and support bone remodeling similar to titanium but also do not accumulate harmful levels of Mg or Gd in organs, making them suitable for use in bone repair.
In this study, the interaction of pure Mg and WE43 alloy under the presence of osteoblast (OB) and osteoclast (OC) cells and their influence on the degradation of materials have been deeply analyzed. Since OB and OC interaction has an important role in bone remodeling, we examined the surface morphology and dynamic changes in the chemical composition and thickness of the corrosion layers formed on pure Mg and WE43 alloy by direct monoculture and coculture of pre-differentiated OB and OC cells in vitro. Electrochemical techniques examined the corrosion performance.
View Article and Find Full Text PDFTreatment of osteoarthritis by implantation of Mg- and WE43-cylinders - A preclinical study on bone and cartilage changes and their influence on pain sensation in rabbits.
Bioact Mater
October 2024
With its main features of cartilage degeneration, subchondral bone sclerosis and osteophyte formation, osteoarthritis represents a multifactorial disease with no effective treatment options. As biomechanical shift in the trabecular network may be a driver for further cartilage degeneration, bone enhancement could possibly delay OA progression. Magnesium is known to be osteoconductive and already showed positive effects in OA models.
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