Publications by authors named "H F Gomes"
Effectiveness of aspiration and the occurrence of adverse effects using the intramuscular route in adults: a systematic review protocol.
JBI Evid Synth
January 2025
Objective: The objective of this review will be to evaluate the effect of prior aspiration versus non-aspiration during intramuscular injection on the occurrence of adverse effects in adult patients.
Introduction: Aspiration is a procedure conducted prior to the administration of intramuscular medications that aims to ensure that the needle tip is inserted in the proper place. Although aspiration is a common procedure, questions have been raised about adverse effects.
Invasive cutaneous melanoma is responsible for about 5% of skin tumors yet is liable for nearly 70% of skin cancer-related deaths. Despite notable advancements over the past decade, including immunotherapies and targeted treatments, more than half of invasive melanoma patients ultimately succumb to the disease due to therapeutic resistance. To overcome this obstacle, strategies such as combining immunotherapies with targeted drugs or adding epigenetic therapies have been investigated.
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- Researchers developed single- and bimetallic carbon xerogels by adding iron and iron-cobalt precursors, testing them in catalytic wet peroxide oxidation (CWPO) to degrade ibuprofen in a simulated environment.
- The bimetallic catalyst showed significantly better performance—25% higher than the single metal and 85% higher than non-metallic catalysts—after 360 minutes of reaction at a mild temperature of 30°C.
- Further optimization for treating hospital wastewater indicated the bimetallic carbon xerogel could achieve up to 80% chemical oxygen demand (COD) removal and 55% total organic carbon (TOC) mineralization in continuous operation, suggesting its potential for efficient wastewater treatment beyond traditional batch methods
Objective: We aimed to assess the effect of N-acetylcysteine (NAC), as an adjuvant treatment, on treatment adherence (primary outcome), in peripheral biomarkers and clinical improvement (secondary outcomes) in alcohol use disorders (AUD) patients.
Methods: A 9-week randomized, double-blind, placebo-controlled trial (RCT) was conducted on 53 (n=25 NAC, n=28 placebo) inpatients with AUD. Neuropeptide Y (NPY), oxidative stress and inflammatory biomarkers, and hepatic parameters were analyzed in three-time moments.