Publications by authors named "H F Escobar-Morreale"
Unveiling Silent Atherosclerosis in Type 1 Diabetes: The Role of Glycoprotein and Lipoprotein Lipidomics, and Cardiac Autonomic Neuropathy.
Metabolites
January 2025
This study aimed to evaluate whether glycoprotein and lipoprotein lipidomics profiles could enhance a clinical predictive model for carotid subclinical atherosclerosis in patients with type 1 diabetes (T1D). Additionally, we assessed the influence of cardiac autonomic neuropathy (CAN) on these predictive models. We conducted a cross-sectional study including 256 patients with T1D.
View Article and Find Full Text PDFComparing quality of life in traditional face-to-face visits with a hybrid approach of telemedicine with in-person follow-ups in recent users of advanced closed-loop systems: a randomized controlled clinical trial in patients with type 1 diabetes.
Ther Adv Endocrinol Metab
October 2024
Background: Our objective was to assess the effect of a hybrid telemedicine approach, in conjunction with face-to-face follow-up, on the quality of life in recent users of an advanced hybrid closed-loop (AHCL) system.
Methods: A 1-year open randomized (1:1) clinical trial (ClinicalTrials.gov ID NCT04900636).
Sexual dimorphism influences cardiovascular outcomes in type 1 diabetes (T1D), with women facing a higher relative risk of macrovascular events compared to men, especially after menopause. This study hypothesizes that abnormalities in intermediate metabolism may be associated with cardiac autonomic neuropathy (CAN) in T1D. We aim to assess low molecular weight metabolites (LMWM) as markers of CAN in T1D, considering the effects of sexual dimorphism and age.
View Article and Find Full Text PDFArticle Synopsis
- Evidence-based guidelines suggest that liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a more accurate method than automated immunoassays for diagnosing biochemical hyperandrogenism in women with polycystic ovary syndrome (PCOS).
- A study involving 359 premenopausal women with symptoms of hyperandrogenism showed that the agreement between results from immunoassays and LC-MS/MS was poor, and LC-MS/MS altered PCOS diagnoses in about 15.8% of the cases.
- The findings indicate that routine immunoassays are unreliable for PCOS phenotyping, and there are inconsistencies in using serum anti-müllerian hormone (AMH) alongside ultrasound for diagnosis, raising
Obesity and polycystic ovary syndrome influence on intestinal permeability at fasting, and modify the effect of diverse macronutrients on the gut barrier.
Food Res Int
June 2024
Article Synopsis
- Women with polycystic ovary syndrome (PCOS) face increased cardiovascular risks and chronic inflammation due to factors like obesity and gut microbiota interactions.
- The study analyzed the impact of macronutrients (glucose, lipids, protein) on intestinal permeability by measuring specific biomarkers among women with PCOS, non-hyperandrogenic women, and men.
- Results showed that obesity heightened certain gut barrier dysfunction markers, and women with PCOS had worsened post-meal responses related to intestinal permeability, indicating interactions between obesity and PCOS affect gut health.