Design, synthesis, and biological activity of D-bishomo-1α,25-dihydroxyvitamin D analogs and their crystal structures with the vitamin D nuclear receptor.

The biologically active metabolite of vitamin D - calcitriol - is a hormone involved in the regulation of calcium-phosphate homeostasis, immunological processes and cell differentiation, being therefore essential for the proper functioning of the human body. This suggests many applications of this steroid in the treatment of diseases such as rickets, psoriasis and some cancers. Unfortunately, using therapeutic doses of calcitriol is associated with high concentrations of this compound which causes hypercalcemia.

Sexual Behaviors, Satisfaction, and Intentions to Engage in Casual Sexual Relationships and Experiences in Emerging Adulthood.

The present study examined the role of sexual behavior and sexual satisfaction in casual sexual relationships and experiences (CSREs) on both immediate and long-term intentions to engage in further CSREs in a sample of emerging adults. We examined how four different operationalizations of sexual behavior (1) Penetrative sexual behaviors not including oral sex vs. non-penetrative sexual behaviors, (2) Penetrative sexual behaviors including oral sex vs.

Antibody production in mice requires neither vitamin D, nor the vitamin D receptor.

The vitamin D receptor as well as its ligand have been localized to various immune tissues and cells. These observations have led researchers to hypothesize a role for vitamin D in the immune system. However, a specific role for vitamin D in immunity has yet to be clearly delineated.

Vitamin D receptor absence does not enhance intestinal tumorigenesis in ApcPirc/+rats.

Epidemiological observations have prompted some to posit that elevated circulating vitamin D is responsible for reduced colon cancer in individuals residing near the equator. We have previously demonstrated that vitamin D has no effect on colon cancer in two rodent models of intestinal tumorigenesis. We have now extended this line of inquiry to ask whether ablation of vitamin D receptor (VDR) affects tumorigenesis.