Publications by authors named "H F BLUM"
[150 years of gastroenterology in the DMW - from Kussmaul to AI].
Dtsch Med Wochenschr
December 2024
The Deutsche Medizinische Wochenschrift has accompanied the diverse and dynamic developments in the field of gastroenterology since the first issue of the journal in 1875! This article examines gastroenterological publications that have been published in the DMW over its 150-year history - some of which have marked milestones in this medical field.
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- Sulfur mustard (SM) is a toxic chemical agent that causes severe skin lesions and impairs wound healing, with no current effective treatments available.
- Research identified a pathomechanism involving the miRNA miR-497-5p and survivin, which leads to keratinocyte dysfunction after SM exposure.
- Inhibiting miR-497-5p improved keratinocyte proliferation and differentiation, and using lipid-nanoparticles to deliver the inhibitor promoted skin recovery in human biopsies, suggesting potential therapeutic strategies for SM exposure.
Leaf parsley growth and productivity are often affected by pathogen infection. Root-knot nematodes of the genus are common pathogens reported on leaf parsley. The response of leaf parsley to species in tropical and subtropical regions is quite known, while in temperate regions, comparable information is still scarce.
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- Parapoxviruses (PPVs) are globally spread viruses affecting livestock, with well-studied species in small ruminants but less known genomes in large ruminants.
- The study utilized Nanopore sequencing to analyze the whole genome sequences of several strains, including Bovine papular stomatitis virus (BPSV) and Pseudocowpox virus (PCPV), revealing important genomic features and variability.
- This approach improved the accuracy of phylogenetic comparisons among PPV genomes and allowed for better identification of new Poxvirus species, enhancing understanding in virus diagnostics.
Innate antiviral factors are essential for effective defense against viral pathogens. However, the identity of major restriction mechanisms remains elusive. Current approaches to discover antiviral factors usually focus on the initial steps of viral replication and are limited to a single round of infection.
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