Publications by authors named "H Ewers"
Article Synopsis
- The text discusses how cellular membrane balance (homoeostasis) is maintained through regulated transport processes between organelles involved in endocytosis and secretion.
- This process is facilitated by adaptor protein complexes (APs) that are recruited by the small GTPase ARF1, aiding in cargo selection for membrane trafficking.
- The study identifies two distinct roles of ARF1 compartments in facilitating secretory cargo export from the Golgi and recycling of materials from endosomes, challenging the conventional understanding of vesicle transport.
Small antigen binders, such as nanobodies, have become widely used in biomedical research and pharmaceutical development. However, the pipeline for the generation of functional conjugated probes and drugs from identified binders remains a major time-consuming bottleneck. Here, we developed a method for fast nanobody production and conjugation based on an in vitro synthesis platform.
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- Most mammalian cells possess circadian clocks that regulate the timing of various biological processes, but how they adapt to changes in metabolism is not well understood.* -
- This study utilized single-cell analysis to explore the relationship between circadian rhythms and protein stability without altering genes, focusing on key proteins involved in the circadian clock.* -
- Findings revealed that the duration of circadian rhythms adjusts based on the degradation rates of repressor proteins, with stability influenced by the phase of the circadian cycle, challenging existing theories about these mechanisms.*
Brain function emerges from a highly complex network of specialized cells that are interlinked by billions of synapses. The synaptic connectivity between neurons is established between the elongated processes of their axons and dendrites or, together, neurites. To establish these connections, cellular neurites have to grow in highly specialized, cell-type dependent patterns covering extensive distances and connecting with thousands of other neurons.
View Article and Find Full Text PDFExpansion microscopy (ExM) is a revolutionary novel approach to increase resolution in light microscopy. In contrast to super-resolution microscopy methods that rely on sophisticated technological advances, including novel instrumentation, ExM instead is entirely based on sample preparation. In ExM, labeled target molecules in fixed cells are anchored in a hydrogel, which is then physically enlarged by osmotic swelling.
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