Risperidone and ethyl pyruvate have protective effects against ketamine-induced cognitive impairments in mice.

Objective: Ketamine, an N-methyl D-aspartic acid receptor antagonist drug, is reported to produce memory disruptions. The aim of this study was to investigate the protective effects of ethyl pyruvate (EP), a pyruvic acid derivative, and risperidone, an atypical antipsychotic drug, against ketamine-induced cognitive disturbances.

Materials And Methods: A passive-avoidance test, a novel object recognition test, and a modified elevated plus maze test were used to assess memory functions.