Publications by authors named "H Engelstaedter"
Mechanical ventilation is a life-saving clinical treatment but it can induce or aggravate lung injury. New therapeutic strategies, aimed at reducing the negative effects of mechanical ventilation such as excessive production of reactive oxygen species, release of pro-inflammatory cytokines, and transmigration as well as activation of neutrophil cells, are needed to improve the clinical outcome of ventilated patients. Though the inhaled anesthetic sevoflurane is known to exert organ-protective effects, little is known about the potential of sevoflurane therapy in ventilator-induced lung injury.
View Article and Find Full Text PDFArticle Synopsis
- The document addresses an error in the original article identified by the DOI: 10.1155/2017/3715037.!
- It provides corrective information necessary to clarify the content or findings of the original study.!
- The corrections aim to enhance the accuracy and reliability of the research presented in the article.!
Article Synopsis
- Acute lung injury (ALI) from septic causes is a significant issue for patients in critical care, and previous research indicated that hydrogen sulfide (HS) could have protective effects against inflammation in the lungs.
- In this study, mice were exposed to lipopolysaccharide (LPS) to simulate ALI, and those inhaling HS showed reduced lung damage and inflammation compared to those who did not.
- The inhalation of HS appeared to work by blocking several harmful signaling pathways associated with inflammation and oxidative stress, preventing the typical lung injury caused by LPS exposure.
Article Synopsis
- - This text indicates that there is a correction made to an article published under the DOI 10.1371/journal.pone.0176649.
- - The correction could involve inaccuracies or errors in the original publication that need to be addressed for clarity or accuracy.
- - Readers should refer to the corrected version to ensure they have the most accurate information from the study.
Although essential in critical care medicine, mechanical ventilation often results in ventilator-induced lung injury. Low concentrations of hydrogen sulfide have been proven to have anti-inflammatory and anti-oxidative effects in the lung. The aim of this study was to analyze the kinetic effects of pre- and posttreatment with hydrogen sulfide in order to prevent lung injury as well as inflammatory and oxidative stress upon mechanical ventilation.
View Article and Find Full Text PDF