Publications by authors named "H Elflein"
Aim: The purpose of this study was to assess the prevalence of strabismus and nystagmus and to analyse associated factors in preterm and full-term infants in adulthood.
Methods: The Gutenberg Prematurity Eye Study is a retrospective cohort study with a prospective ophthalmological examination of participants born preterm and full-term (aged 18-52 years). Perinatal data were carefully assessed for risk factors and comprehensive ophthalmological examinations were conducted.
Context: Inhibition of the neonatal fragment crystallizable receptor (FcRn) reduces pathogenic thyrotropin receptor antibodies (TSH-R-Ab) that drive pathology in thyroid eye disease (TED).
Objective: We report the first clinical studies of an FcRn inhibitor, batoclimab, in TED.
Design: Proof-of-concept (POC) and randomized, double-blind placebo-controlled trials.
Article Synopsis
- The study investigates ocular health and care in adults who were either preterm or full-term babies, focusing on those born between 1969 and 2002.
- It shows that higher rates of strabismus (crossed eyes) and lower rates of recent eye exams are found in those born extremely preterm, with and without retinopathy of prematurity (ROP).
- The findings suggest a need for improved ophthalmological care and monitoring for individuals who were born preterm, especially those with a history of ROP.
Article Synopsis
- The study aimed to assess the ophthalmologic care received by preterm and full-term infants during childhood and adolescence, based on feedback from their parents.
- It involved a retrospective cohort study where parents of individuals, now aged 18 to 52, were interviewed about the eye care their children received, with participants categorized based on gestational age and presence of retinopathy of prematurity (ROP).
- Results showed high satisfaction with the eye care provided, particularly for children with ROP, noting that most parents felt the treatment was adequate, although some reported changing ophthalmologists due to dissatisfaction.
Thyroid eye disease (TED) involves several pathogenic pathways and a battery of infiltrating mononuclear cells, cytokines, and chemokines in the orbit. Revealing the main molecules, which play a major role in the pathogenesis of TED, will help developing novel treatment strategies. In a multicenter, single-blind, case-control study, 60 tissue samples were collected during orbital decompression (44 TED patients) or non-TED related oculoplastic (16 controls) surgeries.
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