Adipocytokine expression associated with miRNA regulation and diagnosis of NASH in obese patients with NAFLD.

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is strongly associated with visceral adiposity. The secretion of adipocytokines from white adipose tissue (WAT) promoting necroinflammation, and/or fibrosis may play important roles in the pathogenesis of non-alcoholic steatohepatits (NASH). In a previous study, reduced expression of a number of miRNA species in WAT concomitant with histological diagnosis of NASH was successfully demonstrated.

Differential expression of miRNAs in the visceral adipose tissue of patients with non-alcoholic fatty liver disease.

Background: Progression of non-alcoholic fatty liver disease (NAFLD) can be facilitated by soluble molecules secreted by visceral adipose tissue (VAT). MicroRNAs (miRNAs) are likely to regulate some of these molecular pathways involved in pathogenesis of NAFLD.

Aim: To profile miRNA expression in the visceral adipose tissue of patients with NAFLD.