Publications by authors named "H Edward Grotjan"
Over 1000 children affected with cystic fibrosis (CF) are born annually in the USA. Since IVF with preimplantation genetic diagnosis (PGD) is an alternative to raising a sick child or to aborting an affected fetus, a cost-benefit analysis was performed for a national IVF-PGD program for preventing CF. The amount spent to deliver healthy children for all CF carrier-couples by IVF-PGD was compared with the average annual and lifetime direct medical costs per CF patient avoided.
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- The study looked at 2,167 IVF treatments to see how successful they were in helping women get pregnant.
- As women tried more IVF cycles, they were usually older, and fewer eggs were retrieved in later attempts.
- The chances of getting pregnant decreased significantly after the third IVF cycle, so women who don’t get pregnant after three tries should think about other options.
Background: The objective of this study was to examine the effect of BMI on IVF outcomes.
Methods: This was a retrospective analysis of all patients undergoing IVF from 1st January 2005 to 1st March 2006 in a large private practice using a single IVF laboratory. The patients underwent standard protocols for controlled ovarian hyperstimulation and embryology parameters.
Article Synopsis
- The study looked at two different treatments for helping women get pregnant using IVF from 2001 to 2003.
- One treatment was recombinant FSH (r-FSH) alone, while the other was a mix of r-FSH and human menopausal gonadotrophin (HMG).
- The results showed r-FSH alone helped get more eggs and had better overall success rates, but both treatments had similar live birth rates and miscarriage risks.
Chorionic gonadotropins (CG) are unique because they have a carboxyl terminal peptide (CTP) extension on their beta subunits that prolongs circulatory survival. CGbeta genes from the human being and horse have evolved from ancestral luteinizing hormone (LH) beta genes by different pathways that involve deletions that change the reading frames and yield a CTP. Here we further review our previous analysis, aimed at determining whether LHbeta genes in non-primate, non-equid species inherently possess DNA sequences that encode CTP-like domains.
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