Publications by authors named "H Edington"
Article Synopsis
- A multi-center study reviewed 36 cases of pediatric patients with EBV(-)M-PTLD, highlighting demographics, treatment regimens, and outcomes between 2001 and 2020.
- Results showed a median follow-up of 3 years, with 3-year event-free survival at 64.8% and overall survival at 79.9%, suggesting outcomes similar to EBV(+) PTLD but less favorable than mature B-cell lymphoma in healthy children.
Article Synopsis
- - PSOT-BL, a rare and aggressive form of cancer in children post-organ transplantation, was studied in 35 patients across 14 hospitals in the U.S., with a median age of diagnosis at 8 years, mostly occurring over 2 years after transplant.
- - The most commonly transplanted organs were the heart and liver, and despite the severity of the disease, patients did not experience graft loss or treatment-related deaths.
- - Various treatment regimens were employed, showing a 3-year event-free survival rate of 66.2% and overall survival rate of 88%, indicating that intensive treatments for PSOT-BL can achieve outcomes similar to those in healthy children with Burkitt lymphoma.
Pediatric Evans syndrome (pES) is increasingly identified as the presenting manifestation of several inborn errors of immunity. Despite an improved understanding of genetic defects in pES, the underlying immunobiology of pES is poorly defined, and characteristic diagnostic immune parameters are lacking. We describe the immune characteristics of 24 patients with pES and compared them with 22 patients with chronic immune thrombocytopenia (cITP) and 24 healthy controls (HCs).
View Article and Find Full Text PDFPurpose: T cell-Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (T cell-EBV-HLH) is prevalent in East Asia and has poor prognosis. Understanding of this disease is limited, and literature regarding prevalence in North America is scarce. Herein, we summarize our experience.
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