Cardioprotective potential of tectochrysin against vanadium induced heart damage via regulating NLRP3, JAK1/STAT3 and NF-κB pathway.

Background: Vanadium (VAN) is a significant trace element, but its higher exposure is reported to cause severe organ toxicity. Tectochrysin (TEC) is a naturally derived flavonoid which demonstrates a wide range of pharmacological properties.

Aim: The current study was planned to assess the cardioprotective potential of TEC against VAN induced cardiotoxicity in rats via regulating biochemical, and histological profile.

Eco-Friendly Fire-Retardant Coating on Cotton Using Layer by Layer Deposition Technique.

Fire hazards are an increasing concern in several high-tech industries of public importance, particularly where textile fabrics are used in abundance. In this study, a novel layer by layer deposition method was utilized to develop a fire-retardant coating on cotton fabric. The method involves a hybrid cationic solution consisting of chitosan and branched polyethyleneimine, while bentonite clay was used as the anionic species.

A Soft Robotic Sleeve for Physiotherapy: Improving Elbow Rehabilitation in Baseball Pitchers.

Background And Purpose: Throwing a baseball involves intense exposure of the arm to high speeds and powerful forces, which contributes to an increasing prevalence of arm injuries among athletes. Traditional rigid exoskeletons and rehabilitation equipment frequently lack portability, safety, ergonomic design, and affordability. Traditional rehabilitation approaches frequently require therapist monitoring, resulting in therapy delays.

Synthesis, Characterization and Application of Iron (III) Complex of Schiff Base Ligand as a Novel Enhancement Fluorescent Sensor for Al Ion Detection.

This study highlights the importance of developing sensitive and selective sensors for use in pharmaceutical applications for the first time. A novel iron(III)-complex, constructed from unsymmetrical tetradentate NNN'O type Schiff base ligand (E)-3-((6-aminopyridin-2-yl)imino)-1-phenyl butane-1-one (LH) and its structure of it characterized by using various spectroscopic techniques such as FT-IR, UV-Vis, elemental analysis, conductivity, magnetic susceptibility measurements and the TGA method. The correlation of all results revealed that the coordination of the (LH) with the metal ion in a molar ratio of 1:1 leads to the formation of an octahedral geometry around the metal ions.

Identification of acetylcholinesterase inhibitors and stability analysis of THC@HP-β-CD inclusion complex: A comprehensive computational study.

Complexing medications with cyclodextrins can enhance their solubility and stability. In this study, we investigated the host-guest complexation between Tetrahydrocurcumin (THC) and Hydroxypropyl-β-Cyclodextrin (HP-β-CD) using density functional theory (DFT) at the B3LYP-D3/TPZ level of theory in two possible orientations. To determine the reactive sites in both complexes for electrophilic and nucleophilic attacks, we calculated and interpreted the binding energy, HOMO and LUMO orbitals, global chemical reactivity descriptors, natural bond orbital (NBO) analysis, and Fukui indices.