Publications by authors named "H E Siddig"
Machado-Joseph disease (MJD/SCA3) is the most frequent dominant ataxia worldwide. It is caused by a (CAG) expansion. MJD has two major ancestral backgrounds: the Machado lineage, found mainly in Portuguese families; and the Joseph lineage, present in all five continents, probably originating in Asia.
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- The text discusses hereditary spinocerebellar degenerations (SCDs), which are genetic disorders affecting movement and coordination, including conditions like hereditary spastic paraplegia and cerebellar ataxia.
- Researchers studied 90 Sudanese patients from 38 families using advanced genetic techniques and found that a significant portion (63-73%) received genetic diagnoses, often with childhood-onset symptoms.
- The study highlights the genetic diversity of the Sudanese population and the challenges in identifying causative genes, suggesting a potential for discovering new genes related to SCDs in this group.
Background: There is a scarcity of reports from limited-resources countries on functional neurological disorder (FND). We therefore carried out this descriptive study from Sudan to highlight the clinical characteristics of patients and the cultural, diagnostic, and management outcome.
Method: Of 1000 new referrals and patients seen at a central neuropsychiatric clinic in Khartoum, Sudan, 40 fulfilled the criteria for FND.
In this study the clinical manifestation and the effect of corticosteroids on the course and the outcome of post malaria cerebellar ataxia on thirty adult Sudanese patients wr investigated. Twenty four patients with delayed ataxia, that is, ataxia occurring shortly after full recovery from otherwise uncomplicated, documented malaria and six patients who were found to be ataxic on recovery from cerebral malaria were included in the study. The distribution of the age, sex and various clinical aspects were outlined.
View Article and Find Full Text PDFIn this clinical study the presentation, electromyography and nerve conduction studies were described in different types of motor neurone disease in 28 Sudanese patients seen at El Shaab and Khartoum Teaching Hospitals. The three major clinical subtypes encountered were amyotrophic lateral sclerosis (n = 19), progressive bulbar palsy (n = 7) and progressive muscular atrophy (n = 2). Family history of the disease was found in four patients and those mainly presented with bulbar symptoms.
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